The role of free radical scavenger on survival rate after endotoxemia in bile duct ligated rat

Chih Chi Sheen, Hock Liew Eng, Shyr Ming Sheen-Chen

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Free radicals are involved in pathophysiology directly and indirectly in sepsis or endotoxemia. Obstructive jaundice may promote bacterial overgrowth with resultant endotoxemia or sepsis. The purposes of the studies are to test the protective effect of free radical scavenger in obstructive jaundice. Materials and methods: Male Sprague-Dawley rats were randomized to three groups. Group I underwent common bile duct ligation and simultaneously be treated with edaravone (free radical scavenger). Group II underwent common bile duct ligation and simultaneously be treated with normal saline (vehicle). Group III underwent sham operation and simultaneously be treated with edaravone. Lipopolysaccharide (LPS) were injected intraperitoneally the afternoon of third postoperative day. The survival rates after endotoxin challenge were recorded. Results: After endotoxin challenge, the 72 hour survival rates were 33.3%, 8.3% and 58.3% for group 1, 2 and 3 respectively after observation for 72 hours. Conclusion: Edaravone may improve the survival rates in bile duct ligated rats after endotoxin challenge.

原文英語
頁(從 - 到)530-532
頁數3
期刊Biomedical Research (India)
27
發行號2
出版狀態已發佈 - 一月 1 2016
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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