The role of cytokines in endometriosis

Ming Yih Wu, Hong Nerng Ho

研究成果: 雜誌貢獻回顧型文獻

228 引文 斯高帕斯(Scopus)

摘要

Problem: To review the literature on the role of peritoneal cytokines in the pathogenesis and endometriosis-related infertility. Methods of study: A MEDLINE search was conducted by the key words of cytokine and endometriosis in the English publications, and references identified within the identified papers were also reviewed. Results: Several cytokines including interleukin (IL)-l, 6, 8, 10, tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF) were reported to be increased in the peritoneal fluid (PF) of women with endometriosis. Those cytokines may be involved in macrophage activation, inflammatory change and enhanced angiogenesis. However, some cytokines were less expressed such as IL-2, and interferon (IFN)-γ. They reflect the impaired T- and natural killer (NK)-cell function. Endometriotic implants produce some factors, e.g. matrix metalloproteinases (MMPs), Bcl-2, and affect their capacity to implant into the peritoneum. Conclusion: Peritoneal cytokines, which are produced by mesothelial cells, leukocytes and ectopic endometrial cells, interwork locally and systemically in women with endometriosis. More studies about the specific role and interactions of these cytokines are needed to improve the understanding of endometriosis and to develop novel therapies.
原文英語
頁(從 - 到)285-296
頁數12
期刊American Journal of Reproductive Immunology
49
發行號5
DOIs
出版狀態已發佈 - 五月 1 2003
對外發佈Yes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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