The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model

Ting Chen Chang, Yih Huei Uen, Cheng Hung Chou, Joen Rong Sheu, Duen Suey Chou

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Context: Oxidative stress may contribute to lymphedema and subsequent tissue damage. However, the causal role of oxidative stress in lymphedema remains unclear. Objective: We attempted to detect and identify the free radicals formed in lymphedema fluid and assessed the protective mechanisms and effects of specific enzyme inhibitors and natural antioxidants. Materials and methods: To study the level of postsurgical oxidative stress with lymphedema in a mouse tail model, we used an electron spin resonance (ESR) method and an ascorbyl radical's ESR spectrum as an oxidative stress biomarker. The drug-treatment group received an i.p. injection with indomethacin (2mg/kg), baicalein (15mg/kg), MK-886 (3mg/kg), zileuton (6.25mg/kg), diphenyleneiodonium (DPI; 1mg/kg), sulforaphane (30mg/kg), oryzanol (30mg/kg) or sesamol (30mg/kg) once daily for 14d from the day of operation. All animals were sacrificed on day 14. Results: Administration of indomethacin, sulforaphane, oryzanol and sesamol significantly suppressed both the tail volume (56.9%, 77.8%, 72.2% and 38.1% inhibition, respectively, p

原文英語
頁(從 - 到)573-580
頁數8
期刊Pharmaceutical Biology
51
發行號5
DOIs
出版狀態已發佈 - 五月 2013

ASJC Scopus subject areas

  • 藥物發現
  • 藥理
  • 藥學科學
  • 補充和替代醫學
  • 分子醫學

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