The role of autonomic and baroreceptor reflex control in blood pressure dipping and nondipping in rats

Terry B J Kuo, Chun Yu Chen, Yi Ping Wang, Yi Yun Lan, Kai Ho Mak, Guo She Lee, Cheryl C H Yang

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

AIMS:: This study hypothesized that the sleep-wake cycle is the major determinant factor affecting blood pressure (BP) dipping in rats and that the sympathovagal imbalance during quiet sleep is associated with the degree of BP fall. METHODS:: Polysomnographic recording was performed by telemetry on freely moving Wistar-Kyoto rats over 24 h. Active waking and quiet sleep stages were scored using electroencephalogram and electromyogram. BP dipping was assessed as the percentage decline in SBP from dark active waking to light quiet sleep. About 38% of the rats were classified as dippers (>10% dip) and 62% as nondippers (<10% dip). RESULTS:: Among the dipper rats, as compared to dark active waking, the R-R interval and high-frequency power of heart rate variability (a cardiac vagal index) were increased, whereas low-frequency power of blood pressure variability [(BLF), a vascular sympathetic index)] was decreased in light quiet sleep. The sleep-wake cycle rather than the light-dark cycle played the major role in determining BP dipping. The light-dark change in R-R interval, BLF during dark active waking, and baroreflex sensitivity indices during quiet sleep were significantly lower among nondipper rats than among dipper rats. Correlation analysis revealed that BLF during dark active waking as well as high-frequency power of heart rate variability and baroreflex sensitivity indices during light quiet sleep were correlated with the BP dipping percentage. CONCLUSION:: This study confirms that the sleep-wake cycle is more important than the light-dark cycle in determining BP dipping. Moreover, lower baroreflex control and parasympathetic activity during quiet sleep as well as lower sympathetic activity during active waking are associated with reduced BP dipping.
原文英語
頁(從 - 到)806-816
頁數11
期刊Journal of Hypertension
32
發行號4
DOIs
出版狀態已發佈 - 2014
對外發佈Yes

指紋

Baroreflex
Sleep
Blood Pressure
Light
Photoperiod
Heart Rate
Telemetry
Inbred WKY Rats
Sleep Stages
Electromyography
Blood Vessels
Electroencephalography

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

引用此文

The role of autonomic and baroreceptor reflex control in blood pressure dipping and nondipping in rats. / Kuo, Terry B J; Chen, Chun Yu; Wang, Yi Ping; Lan, Yi Yun; Mak, Kai Ho; Lee, Guo She; Yang, Cheryl C H.

於: Journal of Hypertension, 卷 32, 編號 4, 2014, p. 806-816.

研究成果: 雜誌貢獻文章

Kuo, Terry B J ; Chen, Chun Yu ; Wang, Yi Ping ; Lan, Yi Yun ; Mak, Kai Ho ; Lee, Guo She ; Yang, Cheryl C H. / The role of autonomic and baroreceptor reflex control in blood pressure dipping and nondipping in rats. 於: Journal of Hypertension. 2014 ; 卷 32, 編號 4. 頁 806-816.
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abstract = "AIMS:: This study hypothesized that the sleep-wake cycle is the major determinant factor affecting blood pressure (BP) dipping in rats and that the sympathovagal imbalance during quiet sleep is associated with the degree of BP fall. METHODS:: Polysomnographic recording was performed by telemetry on freely moving Wistar-Kyoto rats over 24 h. Active waking and quiet sleep stages were scored using electroencephalogram and electromyogram. BP dipping was assessed as the percentage decline in SBP from dark active waking to light quiet sleep. About 38{\%} of the rats were classified as dippers (>10{\%} dip) and 62{\%} as nondippers (<10{\%} dip). RESULTS:: Among the dipper rats, as compared to dark active waking, the R-R interval and high-frequency power of heart rate variability (a cardiac vagal index) were increased, whereas low-frequency power of blood pressure variability [(BLF), a vascular sympathetic index)] was decreased in light quiet sleep. The sleep-wake cycle rather than the light-dark cycle played the major role in determining BP dipping. The light-dark change in R-R interval, BLF during dark active waking, and baroreflex sensitivity indices during quiet sleep were significantly lower among nondipper rats than among dipper rats. Correlation analysis revealed that BLF during dark active waking as well as high-frequency power of heart rate variability and baroreflex sensitivity indices during light quiet sleep were correlated with the BP dipping percentage. CONCLUSION:: This study confirms that the sleep-wake cycle is more important than the light-dark cycle in determining BP dipping. Moreover, lower baroreflex control and parasympathetic activity during quiet sleep as well as lower sympathetic activity during active waking are associated with reduced BP dipping.",
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AU - Kuo, Terry B J

AU - Chen, Chun Yu

AU - Wang, Yi Ping

AU - Lan, Yi Yun

AU - Mak, Kai Ho

AU - Lee, Guo She

AU - Yang, Cheryl C H

PY - 2014

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N2 - AIMS:: This study hypothesized that the sleep-wake cycle is the major determinant factor affecting blood pressure (BP) dipping in rats and that the sympathovagal imbalance during quiet sleep is associated with the degree of BP fall. METHODS:: Polysomnographic recording was performed by telemetry on freely moving Wistar-Kyoto rats over 24 h. Active waking and quiet sleep stages were scored using electroencephalogram and electromyogram. BP dipping was assessed as the percentage decline in SBP from dark active waking to light quiet sleep. About 38% of the rats were classified as dippers (>10% dip) and 62% as nondippers (<10% dip). RESULTS:: Among the dipper rats, as compared to dark active waking, the R-R interval and high-frequency power of heart rate variability (a cardiac vagal index) were increased, whereas low-frequency power of blood pressure variability [(BLF), a vascular sympathetic index)] was decreased in light quiet sleep. The sleep-wake cycle rather than the light-dark cycle played the major role in determining BP dipping. The light-dark change in R-R interval, BLF during dark active waking, and baroreflex sensitivity indices during quiet sleep were significantly lower among nondipper rats than among dipper rats. Correlation analysis revealed that BLF during dark active waking as well as high-frequency power of heart rate variability and baroreflex sensitivity indices during light quiet sleep were correlated with the BP dipping percentage. CONCLUSION:: This study confirms that the sleep-wake cycle is more important than the light-dark cycle in determining BP dipping. Moreover, lower baroreflex control and parasympathetic activity during quiet sleep as well as lower sympathetic activity during active waking are associated with reduced BP dipping.

AB - AIMS:: This study hypothesized that the sleep-wake cycle is the major determinant factor affecting blood pressure (BP) dipping in rats and that the sympathovagal imbalance during quiet sleep is associated with the degree of BP fall. METHODS:: Polysomnographic recording was performed by telemetry on freely moving Wistar-Kyoto rats over 24 h. Active waking and quiet sleep stages were scored using electroencephalogram and electromyogram. BP dipping was assessed as the percentage decline in SBP from dark active waking to light quiet sleep. About 38% of the rats were classified as dippers (>10% dip) and 62% as nondippers (<10% dip). RESULTS:: Among the dipper rats, as compared to dark active waking, the R-R interval and high-frequency power of heart rate variability (a cardiac vagal index) were increased, whereas low-frequency power of blood pressure variability [(BLF), a vascular sympathetic index)] was decreased in light quiet sleep. The sleep-wake cycle rather than the light-dark cycle played the major role in determining BP dipping. The light-dark change in R-R interval, BLF during dark active waking, and baroreflex sensitivity indices during quiet sleep were significantly lower among nondipper rats than among dipper rats. Correlation analysis revealed that BLF during dark active waking as well as high-frequency power of heart rate variability and baroreflex sensitivity indices during light quiet sleep were correlated with the BP dipping percentage. CONCLUSION:: This study confirms that the sleep-wake cycle is more important than the light-dark cycle in determining BP dipping. Moreover, lower baroreflex control and parasympathetic activity during quiet sleep as well as lower sympathetic activity during active waking are associated with reduced BP dipping.

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KW - Arterial pressure variability

KW - Baroreceptor reflex sensitivity

KW - Heart rate variability

KW - Wireless transmission

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