摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 756-763 |
| 頁數 | 8 |
| 期刊 | Journal of the Formosan Medical Association |
| 卷 | 114 |
| 發行號 | 8 |
| DOIs | |
| 出版狀態 | 已發佈 - 八月 1 2015 |
指紋
ASJC Scopus subject areas
- Medicine(all)
引用此文
The role of adenosine in preconditioning by brief pressure overload in rats. / Huang, Cheng Hsiung; Tsai, Shen Kou; Chiang, Shu Chiung; Lai, Chang Chi; Weng, Zen Chung.
於: Journal of the Formosan Medical Association, 卷 114, 編號 8, 01.08.2015, p. 756-763.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - The role of adenosine in preconditioning by brief pressure overload in rats
AU - Huang, Cheng Hsiung
AU - Tsai, Shen Kou
AU - Chiang, Shu Chiung
AU - Lai, Chang Chi
AU - Weng, Zen Chung
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background/Purpose: Brief pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits has been previously reported. Its effects in other species are not known. This study investigates effects of pressure overload and the role of adenosine in rats in this study. Methods: MI was induced by 40-minute occlusion of the left anterior descending coronary artery followed by 3-hour reperfusion. MI size was determined by triphenyl tetrazolium chloride staining. Brief pressure overload was induced by two 10-minute episodes of partial snaring of the ascending aorta. Systolic left ventricular pressure was raised 50% above the baseline value. Ischemic preconditioning was elicited by two 10-minute coronary artery occlusions. Results: The MI size (mean ± standard deviation), expressed as percentage of area at risk, was significantly reduced in the pressure overload group as well as in the ischemic preconditioning group (17.4 ± 3.0% and 18.2 ± 1.5% vs. 26.6 ± 2.4% in the control group, p <0.001). Pretreatment with 8-(p-sulfophenyl)-theophylline (SPT), an inhibitor of adenosine receptors, did not significantly limit the protection by pressure overload and ischemic preconditioning (18.3 ± 1.5% and 18.2 ± 2.0%, respectively, p <0.001). SPT itself did not affect the extent of infarct (25.4 ± 2.0%). The hemodynamics, area at risk and mortality were not significantly different among all groups of animals. Conclusion: Brief pressure overload of the left ventricle preconditioned rat myocardium against infarction. Because SPT did not significantly alter MI size reduction, our results did not support a role of adenosine in preconditioning by pressure overload in rats.
AB - Background/Purpose: Brief pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits has been previously reported. Its effects in other species are not known. This study investigates effects of pressure overload and the role of adenosine in rats in this study. Methods: MI was induced by 40-minute occlusion of the left anterior descending coronary artery followed by 3-hour reperfusion. MI size was determined by triphenyl tetrazolium chloride staining. Brief pressure overload was induced by two 10-minute episodes of partial snaring of the ascending aorta. Systolic left ventricular pressure was raised 50% above the baseline value. Ischemic preconditioning was elicited by two 10-minute coronary artery occlusions. Results: The MI size (mean ± standard deviation), expressed as percentage of area at risk, was significantly reduced in the pressure overload group as well as in the ischemic preconditioning group (17.4 ± 3.0% and 18.2 ± 1.5% vs. 26.6 ± 2.4% in the control group, p <0.001). Pretreatment with 8-(p-sulfophenyl)-theophylline (SPT), an inhibitor of adenosine receptors, did not significantly limit the protection by pressure overload and ischemic preconditioning (18.3 ± 1.5% and 18.2 ± 2.0%, respectively, p <0.001). SPT itself did not affect the extent of infarct (25.4 ± 2.0%). The hemodynamics, area at risk and mortality were not significantly different among all groups of animals. Conclusion: Brief pressure overload of the left ventricle preconditioned rat myocardium against infarction. Because SPT did not significantly alter MI size reduction, our results did not support a role of adenosine in preconditioning by pressure overload in rats.
KW - Adenosine
KW - Ischemic preconditioning
KW - Myocardial infarction
KW - Pressure overload
KW - Rats
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UR - http://www.scopus.com/inward/citedby.url?scp=84939468317&partnerID=8YFLogxK
U2 - 10.1016/j.jfma.2013.07.014
DO - 10.1016/j.jfma.2013.07.014
M3 - Article
AN - SCOPUS:84939468317
VL - 114
SP - 756
EP - 763
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
SN - 0929-6646
IS - 8
ER -