The risk of hospitalization for motor vehicle accident injury in narcolepsy and the benefits of stimulant use: A nationwide cohort study in Taiwan

Nian Sheng Tzeng, Shih Chun Hsing, Chi Hsiang Chung, Hsin An Chang, Yu Chen Kao, Wei Chung Mao, Cheryl C.H. Yang, Terry B.J. Kuo, Tien Yu Chen, Wu Chien Chien

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Study Objectives: To examine the risk of hospitalization for motor vehicle accident injury (MVAI) in patients with narcolepsy and the effects of stimulant use on MVAI occurrence in patients with narcolepsy. Methods: This is a population-based, retrospective cohort study using Taiwan’s National Health Insurance Research Database between 2000 and 2013. We included patients with narcolepsy based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes, 347. The case and matched control participants were selected in a ratio of 1:3, and the traffic accident (ICD-9-CM codes: E810–E819) plus injury codes (ICD-9-CM codes: 800.xx–999.xx) due to MVAI following hospitalization were used for the study outcome. The type of injury, causes, intentionality, and the effects of stimulant use on patients with narcolepsy were also assessed. Results: A total of 1,316 participants were enrolled, including 329 participants with narcolepsy and 987 participants without narcolepsy. During a 14-year follow-up period, a total of 104 participants had MVAI, of whom 47 (1,559.54 per 100,000 person-years) belonged to the narcolepsy cohort and 57 (556.21 per 100,000 person-years) to the non-narcolepsy cohort. After adjusting for covariates, the risk of hospitalization for MVAI among participants with narcolepsy was still significantly higher than those without narcolepsy (adjusted hazard ratio = 6.725; 95% confidence interval = 4.421–10.231; P < .001). The use of modafinil or methylphenidate, as monotherapy or combined treatment, was associated with a lower risk of MVAI in the narcolepsy cohort. Conclusions: Patients with narcolepsy may have a higher risk of hospitalization for MVAI and stimulant use could mitigate such risk.

原文英語
頁(從 - 到)881-889
頁數9
期刊Journal of Clinical Sleep Medicine
15
發行號6
DOIs
出版狀態已發佈 - 一月 1 2019
對外發佈Yes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

指紋 深入研究「The risk of hospitalization for motor vehicle accident injury in narcolepsy and the benefits of stimulant use: A nationwide cohort study in Taiwan」主題。共同形成了獨特的指紋。

  • 引用此

    Tzeng, N. S., Hsing, S. C., Chung, C. H., Chang, H. A., Kao, Y. C., Mao, W. C., Yang, C. C. H., Kuo, T. B. J., Chen, T. Y., & Chien, W. C. (2019). The risk of hospitalization for motor vehicle accident injury in narcolepsy and the benefits of stimulant use: A nationwide cohort study in Taiwan. Journal of Clinical Sleep Medicine, 15(6), 881-889. https://doi.org/10.5664/jcsm.7842