The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

Shih Yi Lin, Wei Ming Lin, Cheng Li Lin, Tse Yen Yang, Fung Chang Sung, Yuan Hung Wang, Chia Hung Kao

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

原文英語
頁(從 - 到)276-280
頁數5
期刊European Journal of Internal Medicine
25
發行號3
DOIs
出版狀態已發佈 - 2014

指紋

Secondary Hyperparathyroidism
Thyroid Neoplasms
Chronic Kidney Failure
Cohort Studies
Population
Taiwan
Confidence Intervals
Neoplasms
National Health Programs
Proportional Hazards Models
Comorbidity
Retrospective Studies
Databases
Physicians
Research

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

引用此文

The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease : A population based cohort study. / Lin, Shih Yi; Lin, Wei Ming; Lin, Cheng Li; Yang, Tse Yen; Sung, Fung Chang; Wang, Yuan Hung; Kao, Chia Hung.

於: European Journal of Internal Medicine, 卷 25, 編號 3, 2014, p. 276-280.

研究成果: 雜誌貢獻文章

Lin, Shih Yi ; Lin, Wei Ming ; Lin, Cheng Li ; Yang, Tse Yen ; Sung, Fung Chang ; Wang, Yuan Hung ; Kao, Chia Hung. / The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease : A population based cohort study. 於: European Journal of Internal Medicine. 2014 ; 卷 25, 編號 3. 頁 276-280.
@article{90a257e66c5f4e4bafb49498006aa6f2,
title = "The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study",
abstract = "Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95{\%} confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95{\%} confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.",
keywords = "End-stage renal disease, Hyperparathyroidism, Thyroid cancer",
author = "Lin, {Shih Yi} and Lin, {Wei Ming} and Lin, {Cheng Li} and Yang, {Tse Yen} and Sung, {Fung Chang} and Wang, {Yuan Hung} and Kao, {Chia Hung}",
year = "2014",
doi = "10.1016/j.ejim.2014.01.001",
language = "English",
volume = "25",
pages = "276--280",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease

T2 - A population based cohort study

AU - Lin, Shih Yi

AU - Lin, Wei Ming

AU - Lin, Cheng Li

AU - Yang, Tse Yen

AU - Sung, Fung Chang

AU - Wang, Yuan Hung

AU - Kao, Chia Hung

PY - 2014

Y1 - 2014

N2 - Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

AB - Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

KW - End-stage renal disease

KW - Hyperparathyroidism

KW - Thyroid cancer

UR - http://www.scopus.com/inward/record.url?scp=84896397090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896397090&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2014.01.001

DO - 10.1016/j.ejim.2014.01.001

M3 - Article

C2 - 24440084

AN - SCOPUS:84896397090

VL - 25

SP - 276

EP - 280

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

IS - 3

ER -