The relationship between nonalcoholic fatty liver disease and retinopathy in NHANES III

Tzu Yu Lin, Ying Jen Chen, Wei Liang Chen, Tao Chun Peng

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)


Background: Nonalcoholic fatty liver disease (NAFLD), an emerging multisystem disease, has the similar pathogenesis with diabetes and is prevalent in diabetes. This study investigated whether NAFLD is associated with retinopathy in individuals with diabetes and without diabetes. Methods: The association between NAFLD and retinopathy was investigated in 5963 participants aged 40 years and older who participated in the NHANES III, a nationally representative, population-based and cross-sectional study. NAFLD was detected via ultrasonography, and fundus photographs were obtained to grade retinopathy patterns. We performed multivariate logistic regression analysis to investigate the relationship between the presence of retinopathy and NAFLD and diabetes. Results: After adjusting for multiple covariates, NAFLD population had no evidence of retinopathy increase in population without diabetes (odds ratio [OR]: 0.77; 95% confidence interval [CI]: 0.48 to 1.26). In addition, NAFLD in individuals with diabetes was not significantly associated with retinopathy (OR: 0.77; 95% CI: 0.47 to 1.26), independent of age, gender, ethnicity, waist circumference, serum high-density lipoprotein (HDL) cholesterol, serum triglycerides, systolic blood pressure, and glycated hemoglobin. Conclusions: In the US general population, NAFLD is not a precipitating factor of retinopathy in population with or without diabetes.

期刊PLoS One
出版狀態已發佈 - 11月 1 2016

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 農業與生物科學 (全部)


深入研究「The relationship between nonalcoholic fatty liver disease and retinopathy in NHANES III」主題。共同形成了獨特的指紋。