The relation between NEAT1 expression level and survival rate in patients with oral squamous cell carcinoma

Nan Chin Lin, Shih Min Hsia, Tong Hong Wang, Po Jung Li, Yu Hsin Tseng, Kuo Chou Chiu, Hsi Feng Tu, Yin Hwa Shih, Tzong Ming Shieh

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background/purpose: Numerous studies have shown that long noncoding RNAs (lncRNAs) are involved in cancer progression and chemotherapy resistance. Nuclear enriched abundant transcript 1 (NEAT1) is an lncRNA. It affects tumor cell progression and drug resistance in various tumors. However, the relation of NEAT1 and survival rate in oral squamous cell carcinoma (OSCC) requires further study. Materials and methods: One normal gingival epithelium cell line, SG, three oral cancer cell lines (HSC3, OEC-M1, and SAS), 34 paired non-cancerous matched tissues (NCMT), and OSCC tissues were used in this study. Tri-reagent was used for total RNA extraction. NEAT1 expression was assessed by reverse transcription-quantitative PCR (RT-qPCR). Results: NEAT1 expression in oral cancer cell lines was lower than that in normal cells and was significantly downregulated in OSCC. NEAT1 upregulation reduced the survival rate of patients with OSCC. NEAT1 upregulation also reduced the survival rate of OSCC patients treated with chemotherapy and radiotherapy. Conclusion: These results indicate that NEAT1 expression is a valuable biomarker for the prediction and prognosis of oral cancer.
原文英語
期刊Journal of Dental Sciences
DOIs
出版狀態接受/付印 - 2021

ASJC Scopus subject areas

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