The refractory period of transmission is impaired in axonal Guillain-Barré syndrome

Satoshi Kuwabara, Hugh Bostock, Kazue Ogawara, Jia Ying Sung, Kazuaki Kanai, Masahiro Mori, Takamichi Hattori, David Burke

研究成果: 雜誌貢獻文章同行評審

51 引文 斯高帕斯(Scopus)

摘要

Guillain-Barré syndrome (GBS) is classified as acute motor axonal neuropathy (AMAN) or acute inflammatory demyelinating polyneuropathy (AIDP). Motor nerve conduction block is frequently found in both subtypes of GBS. To compare patterns of conduction block and the safety factor for impulse transmission in AMAN and AIDP, pairs of supramaximal stimuli at intervals of 1-5 ms were delivered to stimulate the median nerve at the wrist. At the 2- and 3-ms intervals, compound muscle action potentials (CMAPs) to the second stimulus were significantly smaller in AMAN patients (n = 7) than in normal subjects (n = 10) and AIDP patients (n = 6). Over 4 weeks from onset, the amplitude of both conditioned and unconditioned CMAPs returned toward normal, consistent with improvement in the safety factor for impulse transmission. The refractory period of transmission is impaired in AMAN, and the site of transmission failure is likely to be the motor nerve terminals. In addition to axonal degeneration, the critically but reversibly reduced safety factor is important in the pathophysiology of AMAN, and consistent with the rapid resolution of distal conduction block often seen in AMAN patients.
原文英語
頁(從 - 到)683-689
頁數7
期刊Muscle and Nerve
28
發行號6
DOIs
出版狀態已發佈 - 十二月 2003
對外發佈

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 神經科學 (全部)

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