The Protective Role of Heme Oxygenase-1 Induction on Testicular Tissues After Testicular Torsion and Detorsion

Stone Yang, Hung Jen Shih, Yung Chiong Chow, Pei Shan Tsai, Tao Yeuan Wang, Paulus S. Wang, Chun Jen Huang

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

Purpose: Testicular torsion-detorsion has been identified as an ischemia-reperfusion type of injury. We elucidated the protective role of heme oxygenase-1 super induction on testicular torsion-detorsion injury. Materials and Methods: Adult male Sprague-Dawley rats were randomly allocated to undergo testicular torsion-detorsion, immediately followed by injection of normal saline, the heme oxygenase-1 inducer hemin or hemin plus the heme oxygenase-1 inhibitor tin protoporphyrin. Another set of rats that underwent sham operation, immediately followed by injection of normal saline, hemin or hemin plus tin protoporphyrin, served as controls. Testes were harvested 4 and 24 hours after detorsion, respectively, in the experimental groups or at comparable time points in the control groups. Results: Histological evaluation confirmed that torsion-detorsion caused significant testicular tissue injury. Torsion-detorsion also caused significant increases in the testicular levels of nitric oxide, malondialdehyde, myeloperoxidase activity and heme oxygenase-1. The heme oxygenase-1 inducer hemin significantly enhanced the heme oxygenase-1 expression induced by torsion-detorsion and in turn attenuated testicular injury, and increases in nitric oxide, malondialdehyde and myeloperoxidase activity. In addition, the protective effects of hemin were significantly offset by the heme oxygenase-1 inhibitor tin protoporphyrin. Conclusions: Super induction of heme oxygenase-1 protects testes from torsion-detorsion injury.
原文英語
頁(從 - 到)1928-1933
頁數6
期刊Journal of Urology
177
發行號5
DOIs
出版狀態已發佈 - 五月 2007

ASJC Scopus subject areas

  • 泌尿科學

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