TY - JOUR
T1 - The protective effects of PMC against chronic carbon tetrachloride-induced hepatotocity in vivo
AU - Hsiao, George
AU - Lin, Yun H.
AU - Lin, Chien-Huang
AU - Chou, Duen Suey
AU - Lin, Wen Chun
AU - Sheu, Joen Rong
PY - 2001
Y1 - 2001
N2 - In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.
AB - In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.
KW - 2,2,5,7,8-pentamethyl-6-hydroxychromane
KW - Antioxidant
KW - Carbon tetrachloride
KW - Hepatotoxicity
UR - http://www.scopus.com/inward/record.url?scp=0035159097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035159097&partnerID=8YFLogxK
U2 - 10.1248/bpb.24.1271
DO - 10.1248/bpb.24.1271
M3 - Article
C2 - 11725962
AN - SCOPUS:0035159097
VL - 24
SP - 1271
EP - 1276
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 11
ER -