The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

Gow Chin Yen, Hsing Chang Chiang, Chi Hao Wu, Chi Tai Yeh

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.
原文英語
頁(從 - 到)1561-1567
頁數7
期刊Food and Chemical Toxicology
41
發行號11
DOIs
出版狀態已發佈 - 11月 1 2003
對外發佈

ASJC Scopus subject areas

  • 食品科學
  • 毒理學

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