The prophylactic effects of glutamine on muscle protein synthesis and degradation in rats with ethanol-induced liver damage

Qian Xiao, Yi Hsiu Chen, Satwika Arya Pratama, Ya Ling Chen, Hitoshi Shirakawa, Hsiang Chi Peng, Suh Ching Yang

研究成果: 雜誌貢獻文章同行評審

摘要

The purpose of this research was to investigate the prophylactic effects of glutamine on muscle protein synthesis and degradation in rats with ethanol-induced liver injury. For the first 2 weeks, Wistar rats were divided into two groups and fed a control (n = 16) or glutamine-containing diet (n = 24). For the following 6 weeks, rats fed the control diet were further divided into two groups (n = 8 per group) according to whether their diet contained no ethanol (CC) or did contain ethanol (CE). Rats fed the glutamine-containing diet were also further divided into three groups (n = 8 per group), including a GG group (glutamine-containing diet without ethanol), GE group (control diet with ethanol), and GEG group (glutamine-containing diet with ethanol). After 6 weeks, results showed that hepatic fatty change, inflammation, altered liver function, and hyperammonemia had occurred in the CE group, but these were attenuated in the GE and GEG groups. Elevated intestinal permeability and a higher plasma endotoxin level were observed in the CE group, but both were lower in the GE and GEG groups. The level of a protein synthesis marker (p70S6K) was reduced in the CE group but was higher in both the GE and GEG groups. In conclusion, glutamine supplementation might elevate muscle protein synthesis by improving intestinal health and ameliorating liver damage in rats with chronic ethanol intake.

原文英語
文章編號2788
期刊Nutrients
13
發行號8
DOIs
出版狀態已發佈 - 八月 2021

ASJC Scopus subject areas

  • 食品科學
  • 營養與營養學

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