The pro-apoptotic action of stilbene-induced COX-2 in cancer cells: Convergence with the anti-apoptotic effect of thyroid hormone

Hung Y. Lin, Paul J. Davis, Heng Yuan Tang, Shaker A. Mousa, Mary K. Luidens, Aleck H. Hercbergs, Faith B. Davis

研究成果: 雜誌貢獻回顧型文獻同行評審

29 引文 斯高帕斯(Scopus)

摘要

Constitutively expressed cyclooxygenase-2 (COX-2) is a marker of tumor cell aggressiveness. Inducible COX-2 has also been described in cancer cells and localizes in the cancer cell nucleus, where formation of a complex of mitogen-activated protein kinase (MAPK) and COX-2 is antecedent to p53-dependent apoptosis. The stilbene resveratrol is a model pharmacologic activator of this pro-apoptotic mechanism. Physiological concentrations of thyroid hormone are anti-apoptotic in several types of tumor cells. A mechanism by which the hormone is antiapoptotic is disruption of the nuclear MAPK-COX-2 complex. We review here the apoptosis-relevant effects of resveratrol and thyroid hormone and then speculate about the significance of convergence of these actions in cancer cells in the intact organism. Clinical activity of resveratrol may be modulated by normal tissue levels of endogenous thyroid hormone, and hypothyroidism in the cancer patient - whether spontaneous or induced by chemotherapeutic agents - may permit full expression of the apoptotic activity of the administered stilbene. Chronic pharmacologic inhibition of COX-2 may oppose the pro-apoptotic effect of resveratrol.
原文英語
頁(從 - 到)1877-1882
頁數6
期刊Cell Cycle
8
發行號12
DOIs
出版狀態已發佈 - 六月 15 2009
對外發佈

ASJC Scopus subject areas

  • 分子生物學
  • 發展生物學
  • 細胞生物學

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