The presence of higher levels of thyroglobulin, but not thyroid autoantibodies, in the thyroid vein in Graves’ disease

Fong Fu Chou, Pei Wen Wang, Shyr Ming Sheen-Chen

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

To investigate the possible major source of thyroid autoantibodies production, blood samples were obtained from thyroid vein, jugular vein and peripheral vein during subtotal thyroidectomy in 12 patients with Graves’ disease (11F, 1M; age 16–39 yr). Among them, 7 were treated preoperatively by methimazole, 4 by iopanoic acid and 1 by propranolol. All blood samples were assayed for thyroglobulin (Tg), thyrotropin binding inhibition immunoglobulin (TBII), antithyroglobulin antibody (TgAb) and antimicrosomal antibody (McAb). Tg, a native product of thyroid gland, was markedly elevated in the thyroid veins, over 4 to 6 folds that of jugular veins or peripheral veins. However, the level of thyroid autoantibodies including TBII, TgAb and McAb in the thyroid veins were not significantly different from that in the jugular or peripheral veins. Our preliminary data suggest that it is thyroglobulin, and not thyroid antibodies that is present at higher level in the thyroid vein than the periphery.

原文英語
頁(從 - 到)41-44
頁數4
期刊Journal of Endocrinological Investigation
17
發行號1
DOIs
出版狀態已發佈 - 一月 1994
對外發佈Yes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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