The potential role of phagocytic capacity in the osteolytic process induced by polyethylene wear particles

H. W. Fang, C. B. Yang, C. H. Chang, C. H. Chang, H. L. Liu, S. B. Fang

研究成果: 雜誌貢獻文章

17 引文 斯高帕斯(Scopus)

摘要

Osteolysis induced by ultra-high molecular weight polyethylene wear particles is the major cause of long-term failure of artificial joints. We examined the effects of wear particles on bioactivity by analysing the biophysical aspects of particle phagocytosis. We estimated the maximum number of internalized particles (the phagocytic capacity) for particles of various sizes and shapes. We demonstrated that elongated particles had a smaller phagocytic capacity than spherical particles of the same volume. A review of the literature showed that the ratio of particle concentration (number of particles/number of cells) to phagocytic capacity is critical for particle-induced biological responses. When this ratio was <1, the biological response was approximately proportional to the ratio itself. When this ratio was > 1, limited changes in the biological response were observed. The saturation level of the phagocytic capacity for a particle population appears to reflect the degree of polyethylene particle-induced biological response.
原文英語
頁(從 - 到)655-664
頁數10
期刊Journal of International Medical Research
34
發行號6
出版狀態已發佈 - 十一月 2006
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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