The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation

Ling Chuan Hsu, Bou Yue Peng, May Show Chen, Bahruddin Thalib, Muhammad Ruslin, Tran Dang Xuan Tung, Hsin Hua Chou, Keng Liang Ou

研究成果: 雜誌貢獻文章同行評審

24 引文 斯高帕斯(Scopus)

摘要

In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence-based complementary and alternative medicine for skin regeneration.
原文英語
頁(從 - 到)278-285
頁數8
期刊Journal of Biomedical Materials Research - Part B Applied Biomaterials
107
發行號2
DOIs
出版狀態已發佈 - 二月 1 2019

ASJC Scopus subject areas

  • 生物材料
  • 生物醫學工程

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