The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer

Bor Ching Sheu, Ho Hsiung Lin, Daw Yuan Chang, Hong Nerng Ho, Su Cheng Huang

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case-controlled study. Participants Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study. Methods Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI. Main outcome measures All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression. Results The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r=−0.622, P < 0.0001). Conclusions Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.
原文英語
頁(從 - 到)1314-1319
頁數6
期刊BJOG: An International Journal of Obstetrics and Gynaecology
104
發行號11
DOIs
出版狀態已發佈 - 一月 1 1997
對外發佈Yes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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