The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation

Kuan Chou Chen, Chao Ming Chuang, Li Yun Lin, Wen Ta Chiu, Hui Er Wang, Chiu Lan Hsieh, Tsui Min Tsai, Robert Y. Peng

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.

原文英語
頁(從 - 到)23-31
頁數9
期刊Pharmaceutical Biology
48
發行號1
DOIs
出版狀態已發佈 - 一月 2010

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

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