The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period

An EEG-fMRI study

Fan Chi Hsiao, Pei Jung Tsai, Changwei W. Wu, Chien Ming Yang, Timothy Joseph Lane, Hsin Chien Lee, Ling Chun Chen, We Kang Lee, Lu Hsin Lu, Yu Zu Wu

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as “sleep state misperception.” Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9:00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective-objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower θ power, as well as higher α, β, and γ power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective-objective discrepancy is associated with central nervous system hyperarousal.
原文英語
文章編號zsy056
期刊Sleep
41
發行號6
DOIs
出版狀態已發佈 - 六月 1 2018

指紋

Electroencephalography
Sleep
Magnetic Resonance Imaging
Sleep Stages
Intrinsic Sleep Disorders
Sleep Initiation and Maintenance Disorders
Prefrontal Cortex
Young Adult
Central Nervous System
Power (Psychology)

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

引用此文

The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period : An EEG-fMRI study. / Hsiao, Fan Chi; Tsai, Pei Jung; Wu, Changwei W.; Yang, Chien Ming; Lane, Timothy Joseph; Lee, Hsin Chien; Chen, Ling Chun; Lee, We Kang; Lu, Lu Hsin; Wu, Yu Zu.

於: Sleep, 卷 41, 編號 6, zsy056, 01.06.2018.

研究成果: 雜誌貢獻文章

Hsiao, Fan Chi ; Tsai, Pei Jung ; Wu, Changwei W. ; Yang, Chien Ming ; Lane, Timothy Joseph ; Lee, Hsin Chien ; Chen, Ling Chun ; Lee, We Kang ; Lu, Lu Hsin ; Wu, Yu Zu. / The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period : An EEG-fMRI study. 於: Sleep. 2018 ; 卷 41, 編號 6.
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abstract = "Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as “sleep state misperception.” Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9:00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective-objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower θ power, as well as higher α, β, and γ power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective-objective discrepancy is associated with central nervous system hyperarousal.",
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