The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner, Kelvin K. Tsai, Yuval Shaked

研究成果: 雜誌貢獻回顧型文獻同行評審

55 引文 斯高帕斯(Scopus)

摘要

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

原文英語
頁(從 - 到)225-237
頁數13
期刊Seminars in Cancer Biology
60
DOIs
出版狀態已發佈 - 2月 2020

ASJC Scopus subject areas

  • 癌症研究

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