The molecular structure of a DNA-triostin A complex

Andrew H.J. Wang, Giovanni Ughetto, Gary J. Quigley, Toshio Hakoshima, Gijs A. Van Der Marel, Jacques H. Van Boom, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

249 引文 斯高帕斯(Scopus)

摘要

The molecular structure of triostin A, a cyclic octadepsipeptide antibiotic, has been solved complexed to a DNA double helical fragment with the sequence CGTACG (C, cytosine; G, guanine; T, thymine; A, adenine). The two planar quinoxaline rings of triostin A bis intercalate on the minor groove of the DNA double helix surrounding the CG base pairs at either end. The alanine residues form hydrogen bonds to the guanines. Base stacking in the DNA is perturbed, and the major binding interaction involves a large number of van der Waals contacts between the peptides and the nucleic acid. The adenine residues in the center are in the syn conformation and are paired to thymine through Hoogsteen base pairing.

原文英語
頁(從 - 到)1115-1121
頁數7
期刊Science
225
發行號4667
DOIs
出版狀態已發佈 - 1984
對外發佈

ASJC Scopus subject areas

  • 多學科

指紋

深入研究「The molecular structure of a DNA-triostin A complex」主題。共同形成了獨特的指紋。

引用此