The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis

Huey En Tzeng, Syuan Ling Lin, Louis Anoop Thadevoos, Chih Yuan Ko, Ju Fang Liu, Yu Wen Huang, Chih Yang Lin, Yi Chin Fong, Chih Hsin Tang

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.

原文英語
文章編號3347
期刊Cancers
13
發行號13
DOIs
出版狀態已發佈 - 七月 1 2021

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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