The many faces of necrobiosis lipoidica: A report of three cases with histologic variations

Pei Shan Yen, Kuo Hsien Wang, Wei Yu Chen, Ya Wen Yang, Wen Tsao Ho

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

Necrobiosis lipoidica (NL) is a granulomatous disease with unknown etiology and pathogenesis. Clinically, it is characterized by yellow-brown atrophic plaques with inflammatory rims on shins. Histologically, it shows diffused palisade and interstitial granulomatous dermatitis with focal connective tissue degeneration (necrobiosis). We described three non-diabetic NL cases with unusual histologic features. All patients presented erythematous to brownish plaque(s) on the shin(s). In Case 1, in addition to the characteristics of NL, the biopsy showed dense perineural infiltration, which may explain the pathogenesis of the anesthesia of NL lesions. In Case 2, well-formed tuberculoid granulomas were of special interest. In Case 3, there was conspicuous lobular panniculitis. These histologic features present difficulties in the diagnosis and represent the broad spectrum of NL lesions, histologically.
原文英語
頁(從 - 到)67-71
頁數5
期刊Dermatologica Sinica
29
發行號2
DOIs
出版狀態已發佈 - 六月 2011

ASJC Scopus subject areas

  • Dermatology

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