The many blades of the β-propeller proteins: Conserved but versatile

Cammy K.M. Chen, Nei Li Chan, Andrew H.J. Wang

研究成果: 雜誌貢獻回顧型文獻同行評審

117 引文 斯高帕斯(Scopus)

摘要

The β-propeller is a highly symmetrical structure with 4-10 repeats of a four-stranded antiparallel β-sheet motif. Although β-propeller proteins with different blade numbers all adopt disc-like shapes, they are involved in a diverse set of functions, and defects in this family of proteins have been associated with human diseases. However, it has remained ambiguous how variations in blade number could alter the function of β-propellers. In addition to the regularly arranged β-propeller topology, a recently discovered β-pinwheel propeller has been found. Here, we review the structural and functional diversity of β-propeller proteins, including β-pinwheels, as well as recent advances in the typical and atypical propeller structures.

原文英語
頁(從 - 到)553-561
頁數9
期刊Trends in Biochemical Sciences
36
發行號10
DOIs
出版狀態已發佈 - 10月 2011
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學

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