The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries: A systematic review and meta-analysis

Sumit Gupta, Stacy Yeh, Alexandra Martiniuk, Catherine G. Lam, Heui Yang Chen, Yen Lin Liu, Argerie Tsimicalis, Ramandeep S. Arora, Raul C. Ribeiro

研究成果: 雜誌貢獻回顧型文獻同行評審

49 引文 斯高帕斯(Scopus)

摘要

Background Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, centre- and country-specific predictors of abandonment. Patients and Methods We searched seven databases to identify paediatric oncology cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data. Authors were contacted for additional information. Subgroup analyses were planned a priori. Results Of 22,384 publications, 318 in eight languages met criteria for full text review. 157 studies met analysis inclusion criteria. Abandonment rates (ARs), obtained for 83 of the 157 studies (52.9%), ranged from 0% to 74.5%. ARs were frequently unreported and available only directly from authors. Forty studies (10,494 children in 20 countries) were quantitatively analysed. ARs for acute lymphoblastic laeukemia in lower-middle-income countries (lower-MICs) were higher than in upper-middle-income countries (29%, 95% confidence interval (CI) 23-36% versus 2%, 95% CI 1-3%; p < 0.0001) but were heterogeneous (I 2 = 98%; p < 0.0001). This heterogeneity was not explained by centre-specific (free versus paid treatment) or country-specific (government health expenditure, per-capital income) subgroups. Conclusions In LMICs, ARs are highest in lower-MICs. However, their broad range suggests that low ARs are possible in resource-constrained settings. Analysis of outliers may suggest interventions for use at other centres. Methodologically appropriate reporting of ARs should be adopted. Future research should evaluate interventions targeting abandonment.
原文英語
頁(從 - 到)2555-2564
頁數10
期刊European Journal of Cancer
49
發行號11
DOIs
出版狀態已發佈 - 七月 2013
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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