The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

研究成果: 書貢獻/報告類型會議貢獻

摘要

The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.
原文英語
主出版物標題Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
發行者CRC Press/Balkema
頁面359-360
頁數2
ISBN(列印)9781138029415
出版狀態已發佈 - 2016
事件6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, 瑞典
持續時間: 六月 19 2016六月 23 2016

會議

會議6th International Congress on Arsenic in the Environment, AS 2016
國家瑞典
城市Stockholm
期間6/19/166/23/16

    指紋

ASJC Scopus subject areas

  • Pollution
  • Environmental Chemistry

引用此

Wu, C. C., Wang, Y. H., & Hsueh, Y. M. (2016). The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. 於 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (頁 359-360). CRC Press/Balkema.