The joint effect of interleukin-12B rs3212227 genotype and behavioral factors on oral cancer risk in Taiwanese

Ching Hao Li, Kuo Ting Sun, Xin Li, Liang Chun Shih, Liang Yu Chen, Chien Chih Yu, Yun Chi Wang, Wen Shin Chang, Chia Wen Tsai, Chi Yuan Li, Da Tian Bau

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Background/Aim: Oral cancer is of the highest incidence worldwide in Taiwan, and a better marker for personalized therapeutic strategies such as immunotherapies is urgently needed. Interleukin-12 (IL12) is a cytokine that has been reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. The current study aimed at investigating whether IL12B rs3212227 genotype is associated with oral cancer in Taiwan. Materials and Methods: Genotypic characteristics of IL12B rs3212227 were determined among 958 oral cancer cases and age- and gender-matched individuals via typical polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The AA, AC and CC genotypes of IL12B rs3212227 were 38.2, 38.9 and 22.9% in the case group and 36.2, 41.5 and 22.3% in the control group (p=0.5189), respectively. Conclusion: IL12B rs3212227 genotype was associated with oral cancer risk only in betel quid chewers.
原文英語
頁(從 - 到)6515-6521
頁數7
期刊Anticancer Research
39
發行號12
DOIs
出版狀態已發佈 - 2019

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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