The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system

H. O. Ho, F. C. Huang, T. D. Sokoloski, M. T. Sheu

研究成果: 雜誌貢獻文章同行評審

65 引文 斯高帕斯(Scopus)

摘要

The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system was studied using a simplex lattice experimental design. Gel formulations were prepared by gelling the vehicle mixture of water, alcohol and propylene glycol with Carbomer 940. The synthetic membrane Durapore and hairless mouse skin were employed as barriers in a Franz-type diffusion cell. It was found that the penetration through the synthetic membrane was well described by the Higuchi model. There existed a better inverse relationship between the penetration rate and the drug solubility in the respective vehicle. It appeared to be a membrane-controlled mechanism when using hairless mouse skin as the barrier. The penetration rates in steady-state for nine formulations were fitted to a polynomial equation based on this simplex lattice method. A three-dimensional plot was constructed in this simplex surface studied. The maximal penetration rate was found to be from the vehicle containing water and ethanol in an exact volume ratio of 3:1 and the minimal penetration rate was observed from the vehicle containing water only.

原文英語
頁(從 - 到)636-642
頁數7
期刊Journal of Pharmacy and Pharmacology
46
發行號8
出版狀態已發佈 - 1994

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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