摘要
Background: Very few reports are available on the incidence and risk of second primary cancers in nasopharyngeal carcinoma (NPC) cases, and most of these are single-institution reviews with relatively small case numbers and short follow-up. Patients and methods: A population-based study was conducted. We quantified standardized incidence ratios (SIRs) and cumulative incidence of second cancers among 23 639 individuals with initial diagnoses of NPC. Results: We found a 24% increased risk of second cancers in NPC patients compared with the general population [SIR = 1.24, 95% confidence interval 1.15-1.33]. Elevated SIRs were observed in the following second primary cancers: oral/pharyngeal, salivary gland, sarcoma, skin and leukemia/lymphoma. The cumulative incidence >10 years was 3.26%. The risk was higher in younger patients, especially those <40 years old. After diagnosis of second cancers, the median survival time was 1.7 years. Conclusions: This is the largest population-based study to date from a high-incidence area. We found that NPC is associated with an increased risk of second malignancies, which had a negative impact on the survival of patients who survived NPC.
原文 | 英語 |
---|---|
頁(從 - 到) | 1180-1186 |
頁數 | 7 |
期刊 | Annals of Oncology |
卷 | 19 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 6月 2008 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 血液學
- 腫瘤科