The in Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma

Yu Shan Chen, Rou Sun, Wei Lung Chen, Yu Chen Yau, Fei Ting Hsu, Jing Gung Chung, Chia Jung Tsai, Chia Ling Hsieh, Ying Ming Chiu, Jiann Hwa Chen

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Background/Aim: Radiation (RT) induced ERK/NF-?B in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-?B inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have antiinflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-?B-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and-9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NFB-related proteins and increasing the expression of apoptosis-related proteins.
原文英語
頁(從 - 到)1789-1796
頁數8
期刊In Vivo
34
發行號4
DOIs
出版狀態已發佈 - 八月 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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