摘要
Background/Aim: Radiation (RT) induced ERK/NF-?B in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-?B inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have antiinflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-?B-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and-9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NFB-related proteins and increasing the expression of apoptosis-related proteins.
原文 | 英語 |
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頁(從 - 到) | 1789-1796 |
頁數 | 8 |
期刊 | In Vivo |
卷 | 34 |
發行號 | 4 |
DOIs | |
出版狀態 | 已發佈 - 8月 2020 |
ASJC Scopus subject areas
- 生物化學、遺傳與分子生物學 (全部)
- 藥理