The in vivo performance of polyvinyl alcohol macro-encapsulated islets

Zhi Qi, Yanna Shen, Goichi Yanai, Kaichiang Yang, Yasumasa Shirouzu, Akihito Hiura, Shoichiro Sumi

研究成果: 雜誌貢獻文章

25 引文 (Scopus)

摘要

Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA) macro-encapsulated islets (MEI) to treat type 1 DM without any immunotherapy. The present study examined their beneficial effects on islet cryopreservation. PVA MEI of Wistar rats were divided into three groups of 1-day, 7-day and 30-day cryopreservation at -80 °C. The 30-day group showed a lower recovery rate of the islet number and impaired insulin release in comparison to the 1-day group, whereas no significant differences of the in vitro results were observed between the 1-day and 7-day groups. The MEI transplantation recipient mice in the 1-day and 7-day groups reached normoglycemia for a 4-week observation period, and the recipients in 30-day group also showed a significant decrease followed by a slightly higher non-fasting blood glucose level. These results suggest that the PVA MEI are useful for islet long-term cryopreservation, and that the use of cryopreserved PVA MEI may, therefore, be a promising modality for performing DM therapy.
原文英語
頁(從 - 到)4026-4031
頁數6
期刊Biomaterials
31
發行號14
DOIs
出版狀態已發佈 - 五月 2010
對外發佈Yes

指紋

Polyvinyl Alcohol
Polyvinyl alcohols
Cryopreservation
Islets of Langerhans Transplantation
Macros
Medical problems
Type 1 Diabetes Mellitus
Immunotherapy
Insulin
Blood Glucose
Wistar Rats
Diabetes Mellitus
Observation
Glucose
Rats
Blood
Therapeutics
Recovery

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

引用此文

Qi, Z., Shen, Y., Yanai, G., Yang, K., Shirouzu, Y., Hiura, A., & Sumi, S. (2010). The in vivo performance of polyvinyl alcohol macro-encapsulated islets. Biomaterials, 31(14), 4026-4031. https://doi.org/10.1016/j.biomaterials.2010.01.088

The in vivo performance of polyvinyl alcohol macro-encapsulated islets. / Qi, Zhi; Shen, Yanna; Yanai, Goichi; Yang, Kaichiang; Shirouzu, Yasumasa; Hiura, Akihito; Sumi, Shoichiro.

於: Biomaterials, 卷 31, 編號 14, 05.2010, p. 4026-4031.

研究成果: 雜誌貢獻文章

Qi, Z, Shen, Y, Yanai, G, Yang, K, Shirouzu, Y, Hiura, A & Sumi, S 2010, 'The in vivo performance of polyvinyl alcohol macro-encapsulated islets', Biomaterials, 卷 31, 編號 14, 頁 4026-4031. https://doi.org/10.1016/j.biomaterials.2010.01.088
Qi, Zhi ; Shen, Yanna ; Yanai, Goichi ; Yang, Kaichiang ; Shirouzu, Yasumasa ; Hiura, Akihito ; Sumi, Shoichiro. / The in vivo performance of polyvinyl alcohol macro-encapsulated islets. 於: Biomaterials. 2010 ; 卷 31, 編號 14. 頁 4026-4031.
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