Mammographic screening of asymptomatic women leads to the detection of an unprecedented number of in situ and nonpalpable 1-9 mm and 10-14 mm invasive breast cancers. Detecting breast cancer at an earlier phase in its development and at a smaller tumor size is, however, no guarantee that the disease will be localized to a small, confined volume in every case. In fact, multifocal and/or diffuse breast cancers comprise the majority of breast cancers in every size range (Holland et al. 1985; Tot 2007). These studies have also shown that the frequency of unifocal and multifocal breast cancers is unaffected by tumor size at detection (Table 7.1).
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Tabár, L. K., Dean, P. B., Tot, T., Lindhe, N., Ingvarsson, M., & Yen, A. M. F. (2008). The implications of the imaging manifestations of multifocal and diffuse breast cancers. 於 Breast Cancer: A Lobar Disease (頁 87-152). Springer London. https://doi.org/10.1007/978-1-84996-314-5_7