The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for streptococcus pneumoniae carriage in children

Yu Chia Hsieh, Cheng Hsun Chiu, Kuang Yi Chang, Yhu Chering Huang, Chih Jung Chen, Chen Yen Kuo, Po Yen Chen, Kao Pin Hwang, Tzou Yien Lin

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

Background: The aim of the study was to investigate whether the 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors of nasopharyngeal carriage by Streptococcus pneumoniae in children. Methods: From July 2005 through December 2010, we performed a cross-sectional study investigating risk factors associated with pneumococcal carriage in children. Parents of participating children completed questionnaires including whether or not the children received PCV7 vaccination. Results: Among 9705 children, 20.2% of them received at least 1 dose of the PCV7 vaccine. Multivariate logistic regression models identified older age, having 1 sibling in a family, history of acute otitis media and household exposure to smoking as independent risk factors for pneumococcal carriage in the unvaccinated group, but not associated with pneumococcal carriage in the vaccinated group. The number of siblings ≥2 in a family, history of upper respiratory tract infection and child-care attendance were strong factors associated with pneumococcal carriage in children, regardless of vaccination. In vaccinated group, breast-feeding was associated with increased nonvaccine type pneumococcal carriage, mainly in children with upper respiratory tract infection. Conclusions: PCV7 decreased the association between pneumococcal carriage and older age, 1 sibling in a family, history of acute otitis media and household exposure to smoking, but increased the association between pneumococcal carriage and breast-feeding.
原文英語
期刊Pediatric Infectious Disease Journal
31
發行號9
DOIs
出版狀態已發佈 - 九月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

指紋 深入研究「The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for streptococcus pneumoniae carriage in children」主題。共同形成了獨特的指紋。

  • 引用此