The impact of smoking in primary spontaneous pneumothorax

Yeung Leung Cheng, Tsai Wang Huang, Chih Kung Lin, Shih Chun Lee, Ching Tzao, Jen Chih Chen, Hung Chang

研究成果: 雜誌貢獻文章同行評審

60 引文 斯高帕斯(Scopus)

摘要

Background: The crucial role of cigarette smoking in the development of pneumothorax is unclear because nonsmokers can also develop primary spontaneous pneumothorax. The purpose of this study was to clarify the pathophysiologic effects of cigarette smoking and its clinical correlations in primary spontaneous pneumothorax. Methods: Included were 115 specimens of lung tissue from patients with primary spontaneous pneumothorax who underwent video-assisted thoracoscopic surgery from January 2001 to December 2002. We reviewed the clinical features of 56 smokers and 59 nonsmokers with an average follow-up of 67 months. The pathologic findings of resected lung specimens were analyzed retrospectively. Results: There were no statistical differences in sex, age, body height, body weight, body mass index, or the presence of blebs/bullae on computed tomography scans of the lung or under thoracoscopy between the 2 groups. In the smoking group, patients had more extensive respiratory bronchiolitis (P <.001), a high prevalence of tobacco pigmentation (P <.001), and a higher recurrence rate without or after surgery than the nonsmoking group (57% vs 22%, P = .001 and 8.9% vs 1.7%, P = .02, respectively). Patients with extensive respiratory bronchiolitis had significantly higher nonoperative and postoperative recurrences than patients with nonextensive respiratory bronchiolitis (P = .004 and P <.001, respectively). Conclusion: Cigarette smoking is associated with the pathophysiologic consequences of extensive respiratory bronchiolitis, which had a significant impact on the recurrence rates of primary spontaneous pneumothorax.

原文英語
頁(從 - 到)192-195
頁數4
期刊Journal of Thoracic and Cardiovascular Surgery
138
發行號1
DOIs
出版狀態已發佈 - 七月 2009
對外發佈

ASJC Scopus subject areas

  • 心臟病學與心血管醫學
  • 肺和呼吸系統醫學
  • 手術

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