The impact of diabetes mellitus and its control on the development of tuberculosis

A nationwide longitudinal study in Taiwan

Ming Chia Lee, Chih Hsin Lee, Chin Chung Shu, Wei Bang Pong, Chou Chin Lan, Jann Yuan Wang, Li Na Lee, Kun Mao Chao

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Purpose: Diabetic mellitus (DM) is a well-known risk factor of tuberculosis (TB). However, there is paucity of reports on the impact of diabetic control and adherence to anti-diabetic treatment on the risk of TB. This nationwide cohort study aimed to address these issues. Methods: In the Longitudinal Health Insurance Database 2005 of Taiwan, DM cases and matched control subjects were selected. Potential risk factors for developing TB were investigated using the Cox proportional hazards regression analysis. Time-dependent variables were used to measure drug prescription, adherence, and number of DM-associated admissions from 360 to 90days prior to each outcome event. Results: The 49903 DM patients identified (52.5% males) had a mean age of 61.9±14.2years. Among DM patients and control subjects, the independent risk factors of TB were age, male sex, chronic obstructive pulmonary disease (COPD), autoimmune disease, and DM (hazard ratio [HR] 1.293 [1.154-1.449]). Among DM patients, time-dependent Cox analysis revealed that age, male sex, COPD, end-stage renal disease, maximum average daily dose of oral hypoglycemic agent (HR 1.13 [1.071-1.193]), insulin use during admission (HR 1.462 [1.087-1.966]), adherence to anti-diabetic medication (0.577 [0.429-0.776]), and number of DM-associated admissions (1.789 [1.231-2.601]) were independent factors associated with the development of TB. Conclusions: The risk of TB parallels DM severity. Some cases of TB can be prevented by fostering adherence to anti-diabetic medication.

原文英語
頁(從 - 到)995-1003
頁數9
期刊Pharmacoepidemiology and Drug Safety
22
發行號9
DOIs
出版狀態已發佈 - 九月 2013
對外發佈Yes

指紋

Taiwan
Longitudinal Studies
Diabetes Mellitus
Tuberculosis
Chronic Obstructive Pulmonary Disease
Drug Prescriptions
Foster Home Care
Health Insurance
Hypoglycemic Agents
Autoimmune Diseases
Chronic Kidney Failure
Cohort Studies
Regression Analysis
Databases
Insulin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Epidemiology

引用此文

The impact of diabetes mellitus and its control on the development of tuberculosis : A nationwide longitudinal study in Taiwan. / Lee, Ming Chia; Lee, Chih Hsin; Shu, Chin Chung; Pong, Wei Bang; Lan, Chou Chin; Wang, Jann Yuan; Lee, Li Na; Chao, Kun Mao.

於: Pharmacoepidemiology and Drug Safety, 卷 22, 編號 9, 09.2013, p. 995-1003.

研究成果: 雜誌貢獻文章

Lee, Ming Chia ; Lee, Chih Hsin ; Shu, Chin Chung ; Pong, Wei Bang ; Lan, Chou Chin ; Wang, Jann Yuan ; Lee, Li Na ; Chao, Kun Mao. / The impact of diabetes mellitus and its control on the development of tuberculosis : A nationwide longitudinal study in Taiwan. 於: Pharmacoepidemiology and Drug Safety. 2013 ; 卷 22, 編號 9. 頁 995-1003.
@article{0afd02f581cd4b92a1b831367c2f0b1c,
title = "The impact of diabetes mellitus and its control on the development of tuberculosis: A nationwide longitudinal study in Taiwan",
abstract = "Purpose: Diabetic mellitus (DM) is a well-known risk factor of tuberculosis (TB). However, there is paucity of reports on the impact of diabetic control and adherence to anti-diabetic treatment on the risk of TB. This nationwide cohort study aimed to address these issues. Methods: In the Longitudinal Health Insurance Database 2005 of Taiwan, DM cases and matched control subjects were selected. Potential risk factors for developing TB were investigated using the Cox proportional hazards regression analysis. Time-dependent variables were used to measure drug prescription, adherence, and number of DM-associated admissions from 360 to 90days prior to each outcome event. Results: The 49903 DM patients identified (52.5{\%} males) had a mean age of 61.9±14.2years. Among DM patients and control subjects, the independent risk factors of TB were age, male sex, chronic obstructive pulmonary disease (COPD), autoimmune disease, and DM (hazard ratio [HR] 1.293 [1.154-1.449]). Among DM patients, time-dependent Cox analysis revealed that age, male sex, COPD, end-stage renal disease, maximum average daily dose of oral hypoglycemic agent (HR 1.13 [1.071-1.193]), insulin use during admission (HR 1.462 [1.087-1.966]), adherence to anti-diabetic medication (0.577 [0.429-0.776]), and number of DM-associated admissions (1.789 [1.231-2.601]) were independent factors associated with the development of TB. Conclusions: The risk of TB parallels DM severity. Some cases of TB can be prevented by fostering adherence to anti-diabetic medication.",
keywords = "Adherence, Cohort study, Diabetes mellitus, National Health Insurance Database, Pharmacoepidemiology, Tuberculosis",
author = "Lee, {Ming Chia} and Lee, {Chih Hsin} and Shu, {Chin Chung} and Pong, {Wei Bang} and Lan, {Chou Chin} and Wang, {Jann Yuan} and Lee, {Li Na} and Chao, {Kun Mao}",
year = "2013",
month = "9",
doi = "10.1002/pds.3491",
language = "English",
volume = "22",
pages = "995--1003",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - The impact of diabetes mellitus and its control on the development of tuberculosis

T2 - A nationwide longitudinal study in Taiwan

AU - Lee, Ming Chia

AU - Lee, Chih Hsin

AU - Shu, Chin Chung

AU - Pong, Wei Bang

AU - Lan, Chou Chin

AU - Wang, Jann Yuan

AU - Lee, Li Na

AU - Chao, Kun Mao

PY - 2013/9

Y1 - 2013/9

N2 - Purpose: Diabetic mellitus (DM) is a well-known risk factor of tuberculosis (TB). However, there is paucity of reports on the impact of diabetic control and adherence to anti-diabetic treatment on the risk of TB. This nationwide cohort study aimed to address these issues. Methods: In the Longitudinal Health Insurance Database 2005 of Taiwan, DM cases and matched control subjects were selected. Potential risk factors for developing TB were investigated using the Cox proportional hazards regression analysis. Time-dependent variables were used to measure drug prescription, adherence, and number of DM-associated admissions from 360 to 90days prior to each outcome event. Results: The 49903 DM patients identified (52.5% males) had a mean age of 61.9±14.2years. Among DM patients and control subjects, the independent risk factors of TB were age, male sex, chronic obstructive pulmonary disease (COPD), autoimmune disease, and DM (hazard ratio [HR] 1.293 [1.154-1.449]). Among DM patients, time-dependent Cox analysis revealed that age, male sex, COPD, end-stage renal disease, maximum average daily dose of oral hypoglycemic agent (HR 1.13 [1.071-1.193]), insulin use during admission (HR 1.462 [1.087-1.966]), adherence to anti-diabetic medication (0.577 [0.429-0.776]), and number of DM-associated admissions (1.789 [1.231-2.601]) were independent factors associated with the development of TB. Conclusions: The risk of TB parallels DM severity. Some cases of TB can be prevented by fostering adherence to anti-diabetic medication.

AB - Purpose: Diabetic mellitus (DM) is a well-known risk factor of tuberculosis (TB). However, there is paucity of reports on the impact of diabetic control and adherence to anti-diabetic treatment on the risk of TB. This nationwide cohort study aimed to address these issues. Methods: In the Longitudinal Health Insurance Database 2005 of Taiwan, DM cases and matched control subjects were selected. Potential risk factors for developing TB were investigated using the Cox proportional hazards regression analysis. Time-dependent variables were used to measure drug prescription, adherence, and number of DM-associated admissions from 360 to 90days prior to each outcome event. Results: The 49903 DM patients identified (52.5% males) had a mean age of 61.9±14.2years. Among DM patients and control subjects, the independent risk factors of TB were age, male sex, chronic obstructive pulmonary disease (COPD), autoimmune disease, and DM (hazard ratio [HR] 1.293 [1.154-1.449]). Among DM patients, time-dependent Cox analysis revealed that age, male sex, COPD, end-stage renal disease, maximum average daily dose of oral hypoglycemic agent (HR 1.13 [1.071-1.193]), insulin use during admission (HR 1.462 [1.087-1.966]), adherence to anti-diabetic medication (0.577 [0.429-0.776]), and number of DM-associated admissions (1.789 [1.231-2.601]) were independent factors associated with the development of TB. Conclusions: The risk of TB parallels DM severity. Some cases of TB can be prevented by fostering adherence to anti-diabetic medication.

KW - Adherence

KW - Cohort study

KW - Diabetes mellitus

KW - National Health Insurance Database

KW - Pharmacoepidemiology

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=84882603914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882603914&partnerID=8YFLogxK

U2 - 10.1002/pds.3491

DO - 10.1002/pds.3491

M3 - Article

VL - 22

SP - 995

EP - 1003

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - 9

ER -