The human papillomavirus-16 (HPV-16) oncoprotein E7 conjugates with and mediates the role of the transforming growth factor-beta inducible early gene 1 (TIEG1) in apoptosis

Hung Shu Chang, Ching Hui Lin, Chien Hui Yang, Yuh Jin Liang, Winston C Y Yu

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

The human papillomavirus (HPV) oncoprotein E7 is a major transforming protein. The E7 protein does not possess intrinsic enzymatic activity, but rather functions through direct and indirect interactions with cellular proteins, several of which are well known cellular tumor suppressors. Using the yeast two-hybrid system, we found that transforming growth factor-beta inducible early gene 1 (TIEG1), a member of the Krüppel-like family (KLF) that has been implicated as a putative tumor suppressor, interacts and forms a specific complex with HPV-16 E7. TIEG1 has been shown to mimic the effects of TGF-beta in various carcinoma cells and plays a critical role in the apoptotic cascade. Our results indicate that E7 binds to the C-terminus of TIEG1 and induces its degradation via the ubiquitin pathway. E7 not only increased the ubiquitination of TIEG1 but also influenced the ability of TIEG1 to affect apoptosis. Our results suggest that suppression of TIEG1-mediated signaling by E7 may contribute to HPV-associated carcinogenesis.
原文英語
頁(從 - 到)1831-1839
頁數9
期刊International Journal of Biochemistry and Cell Biology
42
發行號11
DOIs
出版狀態已發佈 - 十一月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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