The HUman MicroNucleus Project - An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans

Michael Fenech, Nina Holland, Wushou P. Chang, Errol Zeiger, Stefano Bonassi

研究成果: 雜誌貢獻文章同行評審

476 引文 斯高帕斯(Scopus)

摘要

The International Collaborative Project on Micronucleus Frequency in Human Populations (HUMN) was organized to collect data on micronucleus (MN) frequencies in different human populations and different cell types. The test procedures considered by this project are assays using human lymphocytes (cytokinesis-block method), exfoliated epithelial cells, and other cell types. Data (including descriptions of the populations monitored, detailed test protocols, and test results) are being obtained from a large number of laboratories throughout the world and are being entered into a unified database. The information will be used to: (1) determine the extent of variation of 'normal' values for different laboratories and the influence of other factors potentially affecting baseline MN frequency, e.g., age, gender and life-style; (2) provide information on the effect of experimental protocol variations on MN frequency measurements; (3) design and test optimal protocols for the different cell types; and (4) determine the extent to which MN frequency is a valid biomarker of ageing and risk for diseases such as cancer. Copyright (C) 1999 Elsevier Science B.V.

原文英語
頁(從 - 到)271-283
頁數13
期刊Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
428
發行號1-2
DOIs
出版狀態已發佈 - 七月 16 1999
對外發佈

ASJC Scopus subject areas

  • 分子生物學
  • 遺傳學
  • 健康、毒理學和誘變

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