The further characterization of the specifically binding peptide to hepatocellular carcinoma

Yonge Guo, Caixia Ma, Guochao Nie, Chunyan Li, Jinling Wu, Juanjuan Han, Fenghuei Lin, How Tseng, Wei Chen, Weijiang Liang, Yingchun Hou

研究成果: 雜誌貢獻文章

摘要

Previously, we reported a novel 12-mer peptide binding to hepatocellular carcinoma (HCC) cells specifically and sensitively, and it was screened by using a phage displayed peptide library. To identify the potential of this peptide to be used to the early diagnosis and drug delivery of HCC clinic, the synthesized peptide probe was further characterized by using the assays of cell immunofluorescence and tissue chip. The results of cultured cell immunofluorescence assay show that the peptide probe binds to HCC cells with satisfactory specificity and sensitivity. The results of tissue chip show that the peptide probe can bind to the most common types of HCC tissues, especially to the HCC tissues differentiated at grade II. All further characterized results indicate that this peptide is of the great potential to be used as a HCC targeting candidate for the early molecular imaging diagnosis and targeting nanoparticle or drug delivery in HCC clinic practice.

原文英語
文章編號1450070
期刊Biomedical Engineering - Applications, Basis and Communications
26
發行號6
DOIs
出版狀態已發佈 - 十二月 25 2014

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Bioengineering

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