The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies

Bryan Mitton, Er Chieh Cho, Grace I. Aldana-Masangkay, Kathleen M. Sakamoto

研究成果: 雜誌貢獻回顧型文獻

5 引文 斯高帕斯(Scopus)

摘要

Central to discovering novel approaches to treating leukemias and lymphomas is a clear understanding of the signaling networks which lead to unchecked cell cycle progression, proliferation, and survival. Cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) represents a critical integrator of numerous signals from cytoplasmic kinase cascades, and is directly involved in controlling the transcription of genes critical for normal cellular proliferation and survival. Several lines of evidence implicate CREB as a proto-oncogene, as a number of translocations involving CREB and dysregulation of expression are both associated with oncogenesis. Thus, CREB represents a potential therapeutic target in leukemia. Here, we review CREB function and regulation in normal and aberrant hematopoiesis.

原文英語
頁(從 - 到)2057-2063
頁數7
期刊Leukemia and Lymphoma
52
發行號11
DOIs
出版狀態已發佈 - 十一月 2011

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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