The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells

Lu-Yi Yu, Yao-An Shen, Ming-Hung Chen, Yu-Han Wen, Po-I Hsieh, Chun-Liang Lo

研究成果: 雜誌貢獻文章

摘要

Currently, research on cancer therapy is focused on cancer stem cell therapy to overcome drug resistance and tumor recurrence. Although most studies thereof have focused on the effects of functional nanocarriers on cancer therapy, there is little discussion on the effect of nanocarriers on tumor-initiating cancer stem cells (TICSCs) and metastatic cancer stem cells (MCSCs). Therefore, a glutathione (GSH)-responsive micelle, a reactive oxygen species (ROS)-responsive micelle, and a dual GSH-/ROS-responsive micelle were prepared to evaluate the feasibility of using stimuli-responsive micelles to treat TICSCs and MCSCs. The experimental results demonstrate that ROS-responsive and dual ROS-/GSH-responsive micelles efficiently induce the death of both TICSCs and MCSCs because they could release drugs on both CSCs. However, GSH-responsive micelles were sensitive to TICSCs but not to MCSCs because the latter expressed a low GSH level. Relevant results suggest that the micelles with an ROS-responsive characteristic have great potential for delivering payloads efficiently to treat both TICSCs and MCSCs.
原文英語
頁(從 - 到)3109-3118
頁數10
期刊Journal of Materials Chemistry B
7
發行號19
DOIs
出版狀態已發佈 - 2019

引用此文

The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells. / Yu, Lu-Yi; Shen, Yao-An; Chen, Ming-Hung; Wen, Yu-Han; Hsieh, Po-I; Lo, Chun-Liang.

於: Journal of Materials Chemistry B, 卷 7, 編號 19, 2019, p. 3109-3118.

研究成果: 雜誌貢獻文章

Yu, Lu-Yi ; Shen, Yao-An ; Chen, Ming-Hung ; Wen, Yu-Han ; Hsieh, Po-I ; Lo, Chun-Liang. / The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells. 於: Journal of Materials Chemistry B. 2019 ; 卷 7, 編號 19. 頁 3109-3118.
@article{0858c1d26f4c4b3fb102c82bd047ee97,
title = "The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells",
abstract = "Currently, research on cancer therapy is focused on cancer stem cell therapy to overcome drug resistance and tumor recurrence. Although most studies thereof have focused on the effects of functional nanocarriers on cancer therapy, there is little discussion on the effect of nanocarriers on tumor-initiating cancer stem cells (TICSCs) and metastatic cancer stem cells (MCSCs). Therefore, a glutathione (GSH)-responsive micelle, a reactive oxygen species (ROS)-responsive micelle, and a dual GSH-/ROS-responsive micelle were prepared to evaluate the feasibility of using stimuli-responsive micelles to treat TICSCs and MCSCs. The experimental results demonstrate that ROS-responsive and dual ROS-/GSH-responsive micelles efficiently induce the death of both TICSCs and MCSCs because they could release drugs on both CSCs. However, GSH-responsive micelles were sensitive to TICSCs but not to MCSCs because the latter expressed a low GSH level. Relevant results suggest that the micelles with an ROS-responsive characteristic have great potential for delivering payloads efficiently to treat both TICSCs and MCSCs.",
author = "Lu-Yi Yu and Yao-An Shen and Ming-Hung Chen and Yu-Han Wen and Po-I Hsieh and Chun-Liang Lo",
year = "2019",
doi = "10.1039/C8TB02958J",
language = "English",
volume = "7",
pages = "3109--3118",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "19",

}

TY - JOUR

T1 - The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells

AU - Yu, Lu-Yi

AU - Shen, Yao-An

AU - Chen, Ming-Hung

AU - Wen, Yu-Han

AU - Hsieh, Po-I

AU - Lo, Chun-Liang

PY - 2019

Y1 - 2019

N2 - Currently, research on cancer therapy is focused on cancer stem cell therapy to overcome drug resistance and tumor recurrence. Although most studies thereof have focused on the effects of functional nanocarriers on cancer therapy, there is little discussion on the effect of nanocarriers on tumor-initiating cancer stem cells (TICSCs) and metastatic cancer stem cells (MCSCs). Therefore, a glutathione (GSH)-responsive micelle, a reactive oxygen species (ROS)-responsive micelle, and a dual GSH-/ROS-responsive micelle were prepared to evaluate the feasibility of using stimuli-responsive micelles to treat TICSCs and MCSCs. The experimental results demonstrate that ROS-responsive and dual ROS-/GSH-responsive micelles efficiently induce the death of both TICSCs and MCSCs because they could release drugs on both CSCs. However, GSH-responsive micelles were sensitive to TICSCs but not to MCSCs because the latter expressed a low GSH level. Relevant results suggest that the micelles with an ROS-responsive characteristic have great potential for delivering payloads efficiently to treat both TICSCs and MCSCs.

AB - Currently, research on cancer therapy is focused on cancer stem cell therapy to overcome drug resistance and tumor recurrence. Although most studies thereof have focused on the effects of functional nanocarriers on cancer therapy, there is little discussion on the effect of nanocarriers on tumor-initiating cancer stem cells (TICSCs) and metastatic cancer stem cells (MCSCs). Therefore, a glutathione (GSH)-responsive micelle, a reactive oxygen species (ROS)-responsive micelle, and a dual GSH-/ROS-responsive micelle were prepared to evaluate the feasibility of using stimuli-responsive micelles to treat TICSCs and MCSCs. The experimental results demonstrate that ROS-responsive and dual ROS-/GSH-responsive micelles efficiently induce the death of both TICSCs and MCSCs because they could release drugs on both CSCs. However, GSH-responsive micelles were sensitive to TICSCs but not to MCSCs because the latter expressed a low GSH level. Relevant results suggest that the micelles with an ROS-responsive characteristic have great potential for delivering payloads efficiently to treat both TICSCs and MCSCs.

U2 - 10.1039/C8TB02958J

DO - 10.1039/C8TB02958J

M3 - Article

VL - 7

SP - 3109

EP - 3118

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-7518

IS - 19

ER -