The estimation of first-phase insulin secretion by using components of the metabolic syndrome in a Chinese population

Jiunn Diann Lin, Chun Hsien Hsu, Yao Jen Liang, Wei Cheng Lian, Chang Hsun Hsieh, Chung Ze Wu, Dee Pei, Yen Lin Chen

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6 引文 斯高帕斯(Scopus)

摘要

Aims. There are two phases of insulin secretion, the first (FPIS) and second phase (SPIS). In this study, we built equations to predict FPIS with metabolic syndrome (MetS) components and fasting plasma insulin (FPI). Methods. Totally, 186 participants were enrolled. 75% of participants were randomly selected as the study group to build equations. The remaining 25% of participants were selected as the external validation group. All participants received a frequently sampled intravenous glucose tolerance test, and acute insulin response after the glucose load (AIRg) was obtained. The AIRg was considered as FPIS. Results. When MetS components were only used, the following equation was built: log (FPIS) = 1.477-0.119 × fasting plasma glucose (FPG) + 0.079 × body mass index (BMI)-0.523 × high-density lipoprotein cholesterol (HDL-C). After FPI was added, the second equation was formulated: log (FPIS) = 1.532-0.127 × FPG + 0.059 × BMI-0.511 × HDL-C + 0.375 × log (FPI), which provided a better accuracy than the first one. Conclusions. Using MetS components, the FPIS could be estimated accurately. After adding FPI into the equation, the predictive power increased further. We hope that these equations could be widely used in daily practice.

原文英語
文章編號675245
期刊International Journal of Endocrinology
2015
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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