The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation

Yin Cheng Huang, Hung Yu Shih, Sheng Jia Lin, Ching Chi Chiu, Tsu Lin Ma, Tu Hsueh Yeh, Yi Chuan Cheng

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Multiple epigenetic factors play a critical role in cell proliferation and differentiation. However, their function in embryogenesis, especially in neural development, is currently unclear. The Trithorax group (TrxG) homolog KMT2A (MLL1) is an important epigenetic regulator during development and has an especially well-defined role in hematopoiesis. Translocation and aberrant expression of KMT2A is often observed in many tumors, indicating its proto-oncogenic character. Here, we show that Kmt2a was essential for neural development in zebrafish embryos. Disrupting the expression of Kmt2a using morpholino antisense oligonucleotides and a dominant-negative variant resulted in neurogenic phenotypes, including downregulated proliferation of neural progenitors, premature differentiation of neurons, and impaired gliogenesis. This study therefore revealed a novel function of Kmt2a in cell proliferation and differentiation, providing further insight into the function of TrxG proteins in neural development and brain tumors.
原文英語
頁(從 - 到)452-462
頁數11
期刊Developmental Neurobiology
75
發行號5
DOIs
出版狀態已發佈 - 五月 1 2015
對外發佈Yes

指紋

Epigenomics
Neuroglia
Cell Differentiation
Cell Proliferation
Morpholinos
Antisense Oligonucleotides
Hematopoiesis
Zebrafish
Brain Neoplasms
Embryonic Development
Down-Regulation
Embryonic Structures
Phenotype
Neurons
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Medicine(all)

引用此文

The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. / Huang, Yin Cheng; Shih, Hung Yu; Lin, Sheng Jia; Chiu, Ching Chi; Ma, Tsu Lin; Yeh, Tu Hsueh; Cheng, Yi Chuan.

於: Developmental Neurobiology, 卷 75, 編號 5, 01.05.2015, p. 452-462.

研究成果: 雜誌貢獻文章

Huang, Yin Cheng ; Shih, Hung Yu ; Lin, Sheng Jia ; Chiu, Ching Chi ; Ma, Tsu Lin ; Yeh, Tu Hsueh ; Cheng, Yi Chuan. / The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. 於: Developmental Neurobiology. 2015 ; 卷 75, 編號 5. 頁 452-462.
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