The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides

D. B. Jones, F. Kaye, J. Hardman, J. Whang-Peng, N. L. Dale, D. F. Garvin, H. R. Schumacher

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6 引文 斯高帕斯(Scopus)

摘要

The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.
原文英語
頁(從 - 到)67-76
頁數10
期刊Hematologic Pathology
1
發行號1
出版狀態已發佈 - 十二月 1 1987
對外發佈

ASJC Scopus subject areas

  • 病理學與法醫學
  • 血液學

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