The elevation of l-3-hydroxybutyrate concentrations in the serum of aristolochic acid-treated mice

Chien Ming Chen, Tzu Chuan Huang, Jen Ai Lee

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The concentrations of L-3-hydroxybutyrate (L-3HB) in the serum of aristolochic acid (AA)-treated mice were determined by column-switching high-performance liquid chromatography (HPLC). The samples were derivatized with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ) and determined fluorimetrically. Total 3-HB derivatives in serum were separated by an ODS column and then introduced to a sample loop for chiral separation by two tandem CHIRALCEL OD-RH columns. The results showed that the concentration of L-3HB in the serum of normal mice was 0.81 ± 0.15 μM compared to that of AA-treated mice with 4.33 ± 2.81 μM after 3 days and 8.65 ± 2.60 μM after 5 days of AA administration (p

原文英語
頁(從 - 到)25-30
頁數6
期刊International Journal of Bio-Science and Bio-Technology
2
發行號1
出版狀態已發佈 - 三月 2010

ASJC Scopus subject areas

  • 生物醫學工程
  • 生物技術
  • 生物工程
  • 人工智慧

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