The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma

Kuan Chih Chow, Shiow Her Chiou, Shu Peng Ho, Ming Hsui Tsai, Chi Long Chen, Liang Shun Wang, Kwan Hwa Chi

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

We investigated the clinical significance and regulation of serum interleukin-6 (IL-6) in patients with nasopharyngeal carcinoma (NPC). Serum IL-6 levels of 314 NPC patients and 202 healthy individuals were determined. Of the NPC patients, 69.1% (217/314) showed higher IL-6 levels than that of normal average (2.76±2.06 pg/ml). Elevation of IL-6 correlated with the advanced disease and the adverse prognosis of NPC patients. By employing in situ hybridization technique, IL-6 mRNA was detected in the tumor cells of NPC patients with high serum IL-6 levels. Concurrently, serum levels of butyrate were determined in 147 NPC patients and 52 healthy individuals by gas chromatography. Patients with elevated serum butyrate concentrations (4.2±2.2 μM) also had significantly higher IL-6 levels (29.14±5.17 pg/ml). No detectable serum butyrate was measured in the healthy individuals. In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. Our results suggested that tumor cells could be an important source of elevated serum IL-6 in patients with NPC and that IL-6 level in NPC patients was proportional to the serum butyrate concentration. In vitro, IL-6 expression in NPC cells could be up-regulated by butyrate.

原文英語
頁(從 - 到)813-819
頁數7
期刊Oncology Reports
10
發行號4
出版狀態已發佈 - 七月 2003
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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