The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: A randomised controlled trial

Chian Sem Chua, Kuo-Ching Yang, Jui Hao Chen, Yuh Hwa Liu, Yi Hsin Hsu, Hsiu Chuan Lee, Shih-Yi Huang

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p=0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.
原文英語
頁(從 - 到)177-183
頁數7
期刊International Journal of Food Sciences and Nutrition
67
發行號2
DOIs
出版狀態已發佈 - 一月 1 2016

指紋

Grape Seed Extract
Blueberry Plants
grape seed extract
Helicobacter pylori
blueberries
Randomized Controlled Trials
small fruits
Fruit
therapeutics
extracts
placebos
Placebos
Vaccinium macrocarpon
stomach ulcers
constipation
gastritis
Intention to Treat Analysis
cranberries
stomach neoplasms
Proton Pump Inhibitors

ASJC Scopus subject areas

  • Food Science

引用此文

The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication : A randomised controlled trial. / Chua, Chian Sem; Yang, Kuo-Ching; Chen, Jui Hao; Liu, Yuh Hwa; Hsu, Yi Hsin; Lee, Hsiu Chuan; Huang, Shih-Yi.

於: International Journal of Food Sciences and Nutrition, 卷 67, 編號 2, 01.01.2016, p. 177-183.

研究成果: 雜誌貢獻文章

Chua, Chian Sem ; Yang, Kuo-Ching ; Chen, Jui Hao ; Liu, Yuh Hwa ; Hsu, Yi Hsin ; Lee, Hsiu Chuan ; Huang, Shih-Yi. / The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication : A randomised controlled trial. 於: International Journal of Food Sciences and Nutrition. 2016 ; 卷 67, 編號 2. 頁 177-183.
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abstract = "Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64{\%} versus 84.62{\%}, p=0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.",
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