摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 177-183 |
| 頁數 | 7 |
| 期刊 | International Journal of Food Sciences and Nutrition |
| 卷 | 67 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 一月 1 2016 |
指紋
ASJC Scopus subject areas
- Food Science
引用此文
The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication : A randomised controlled trial. / Chua, Chian Sem; Yang, Kuo-Ching; Chen, Jui Hao; Liu, Yuh Hwa; Hsu, Yi Hsin; Lee, Hsiu Chuan; Huang, Shih-Yi.
於: International Journal of Food Sciences and Nutrition, 卷 67, 編號 2, 01.01.2016, p. 177-183.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication
T2 - A randomised controlled trial
AU - Chua, Chian Sem
AU - Yang, Kuo-Ching
AU - Chen, Jui Hao
AU - Liu, Yuh Hwa
AU - Hsu, Yi Hsin
AU - Lee, Hsiu Chuan
AU - Huang, Shih-Yi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p=0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.
AB - Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p=0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.
KW - Blueberry extract
KW - Grape seed extracts
KW - Helicobacter pylori
KW - Polyphenol
UR - http://www.scopus.com/inward/record.url?scp=84964407535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964407535&partnerID=8YFLogxK
U2 - 10.3109/09637486.2016.1144716
DO - 10.3109/09637486.2016.1144716
M3 - Article
C2 - 26883189
AN - SCOPUS:84964407535
VL - 67
SP - 177
EP - 183
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
SN - 0963-7486
IS - 2
ER -