The effects of ferulic acid on nucleus pulposus cells under hydrogen peroxide-induced oxidative stress

Yung Hsin Cheng, Shu Hua Yang, Kai Chiang Yang, Moon Pei Chen, Feng Huei Lin

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

The degeneration of intervertebral disc (IVD) could be divided into 5 stages. In the first and second stages, there are no significant symptoms but could be traced by MRI or CT-scan. Generally, no aggressive treatment would be processed in the clinics. Reactive oxygen species (ROS) has been overproduced in degenerative IVD that could be associated with apoptosis of NP cells and degradation of ECM. Ferulic acid (FA) has been reported an excellent antioxidant and relatively stable in air. The study was aimed to evaluate the therapeutic effects of FA on hydrogen peroxide-induced oxidative stress NP cells and the potential for early treatment in IVD degeneration. The results showed that 500 μM of FA might be the threshold dose to treat NP cells without cytotoxicity. Post-treatment of FA on hydrogen peroxide-induced oxidative stress NP cells significantly up regulated the expression of aggrecan, type II collagen and BMP-7 and down regulated the expression of MMP-3 in mRNA level. Post-treatment of FA on hydrogen peroxide-induced oxidative stress NP cells could restore the production of sulfated-GAGs and inhibit the apoptosis caused by hydrogen peroxide. From the results of the study, FA could be used as a therapeutic agent for NP regeneration in the very near future.
原文英語
頁(從 - 到)1670-1677
頁數8
期刊Process Biochemistry
46
發行號8
DOIs
出版狀態已發佈 - 8月 2011
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 應用微生物與生物技術
  • 生物工程

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