The effects of different epidural analgesia formulas on labor and mode of delivery in nulliparous women

Shin Yan Chen, Pei Lin Lin, Yu Hsuan Yang, Ya Min Yang, Chien Nan Lee, Shou Zen Fan, Li Kuei Chen

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

Objectives: Patient-controlled epidural analgesia (PCEA) and continuous epidural infusion (CEI) are popular and effective methods for pain relief during labor; however, there are concerns about increasing rates of cesarean section (C/S) and instrumental delivery. This prospective study investigated the effect of PCEA and CEI with different formulas on labor and the mode of delivery in nulliparous women. Materials and methods: A total of 480 nulliparous women were randomized into four groups, with 120 in each. Group A received a loading dose of 10mL of 1mg/mL ropivacaine with 2μg/mL fentanyl, then an intermittent bolus of 5mL with a background infusion of 5mL/hour by PCEA. Group B received the same PCEA formula as Group A with 0.8mg/mL bupivacaine. Group C received the same formula as Group A by CEI with 1mg/mL ropivacaine at a rate of 10mL/hour. Group D received the same formula as Group C with 0.8mg/mL bupivacaine. The rates of C/S and instrumental delivery and the incidence of side effects were recorded. Results: The rates of C/S were significantly different between Groups A and C, Groups A and D, and Groups B and D. The rates of instrumental delivery for normal spontaneous delivery were significantly different between Groups A and B, A and D, B and C, and C and D. Conclusion: The C/S rate was higher in Groups C and D; however, the instrumental delivery rate was lower in Groups A and C. We conclude that PCEA with 1mg/mL ropivacaine might provide the greatest benefit for labor analgesia.

原文英語
頁(從 - 到)8-11
頁數4
期刊Taiwanese Journal of Obstetrics and Gynecology
53
發行號1
DOIs
出版狀態已發佈 - 1月 1 2014

ASJC Scopus subject areas

  • 婦產科

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